Dr. Alexander Roland Isaacs

Dr. Alexander Isaacs is the overarching antagonist of the Resident Evil film series. He appeared as a minor villain in Resident Evil: Apocalypse and the main antagonist in both the Resident Evil: Extinction and Resident Evil: The Final Chapter. He was the CEO and co-founder of Umbrella Corporation as well as being the true mastermind behind the orchestrated T-Virus apocalypse. His clone, dubbed "Dr. Sam Isaacs", was an employee at Umbrella and in charge of the Nemesis Program and later the Umbrella Science Division, researching methods to domesticate the infected individuals into a working and military force for Umbrella.

He is the counterpart of Oswell E. Spencer from the game series that the films were based from.

He was portrayed by Iain Glen, who also portrayed Manfred Powell in the 2001 film Lara Croft: Tomb Raider.

Dr. Alexander Isaacs
Dr. Alexander Isaacs is a religious man who had a devout faith in God. He truly believed that Umbrella had to "orchestrate an Apocalypse", similar to the Great Flood God released to cleanse the world of humanity's corruption, leaving a few chosen ones to survive and recreate the world in their own image using Umbrella's advanced technology, manpower of clones and resources. He even wen so far as to use the Holy Bible to prove his point. This shows that he truly is deeply religious and believes in everything he says to the Umbrella High Command. All in all, the original Isaacs was a ruthless and psychopathic individual.

Dr. Sam Isaacs
Dr. Sam Isaacs was a man of cool temperament, being knowledgeable, intelligent, judicious and rationally cruel. Albert Wesker, trying to locate Alice and take a sample of her blood, thus creating a more effective cure to the T-Virus. However, his methods were unorthodox, and he regarded his work with a higher priority than the lives of his colleagues or a few civilians. In fact, one might go as far as to call this version of Isaacs cowardly and arrogant.

This is evidenced by the fact that after the initial test of his serum designed to domesticate zombies failed, and the zombie went berserk, killing a scientist. Dr. Isaacs quickly slipped out of the room, locking the doors and sealing a second scientist inside. That scientist could have easily escaped, had Isaacs quickly let him slip out while the zombie was preoccupied feasting on the first. However, Isaacs coldly watched as the man was ripped apart and eaten alive by the zombie, coolly running his fingers through his hair and adjusting his tie. His instincts for self-preservation also showed itself during the ambush in Las Vegas, when Alice attacked the Umbrella tent. Isaacs quickly fled to the nearby helicopter, leaving his colleagues to die. Isaacs maintained a wary partnership with Alexander Slater, who did not much like the scientist.